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Group members shown in bold, * equal contribution, + corresponding author.
2023
Gao Z+, Zhang Y, Cramer N, Przeworski M, Moorjani P+ (2022). Limited role of generation time changes in driving the evolution of the mutation spectrum in humans. eLife. DOI: https://doi.org/10.7554/eLife.81188. Also on bioRxiv.
Moorjani P and Hellenthal G. Methods for Assessing Population Relationships and History from Genomic Data. Annu. Rev. Genomics & Human Genetics, In Press.
Zhao W, Smith J, Wang YZ, Chintalapati M, Ammous F, Yu M, Moorjani P, Ganna A, Gross A, Dey S, Benerjee J, Chatterjee P, Dey A, Lee J, Sharon L. R. Kardia. Polygenic risk scores for Alzheimer’s disease and general cognitive function are associated with measures of cognition in older South Asians from LASI-DAD. Journal of Gerontology, In Press.
2022
Tournebize R+, Chu G and Moorjani P+. (2022). Reconstructing the history of founder events using genome-wide patterns of allele sharing across individuals. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1010243. Also on bioRxiv.
Featured in: Berkeley News, the Daily Californian, Science Daily, and Science et Avenir.
Chintalapati M+, Patterson N+, Moorjani P+. (2022) Reconstructing the spatiotemporal patterns of admixture during the European Holocene using a novel genomic dating method. eLife. DOI: https://doi.org/10.7554/eLife.77625. Also on bioRxiv.
Featured in: Berkeley News, The Naked Scientists podcast.
2021
, , , , , , , , , , , , , , , , , , , Mutationathon: towards standardization in estimates of pedigree-based germline mutation rates. eLife 2022;11:e73577 DOI: 10.7554/eLife.73577. Also on bioRxiv.
Kim Y*, Leiserson M*, Moorjani P*, Sharan R*, Wojtowicz D* and Przytycka TM. Mutational Signatures: From Methods to Mechanisms. Annu. Rev. Biomed. Data Sci. 2021.4:189-206. (*listed alphabetically, as is convention in mathematics & computer science)
2020
, , , , , A comparison of humans and baboons suggests germline mutation rates do not track cell divisions. PLoS biology. 18, e3000838. Available on bioRxiv. * Co-directed this work.
Smith J, Zhao W, Yu M, Rumfelt, K, Moorjani P, Ganna A, Dey A, Lee J, Kardia S. (2020). Association between Alzheimer’s Disease risk SNPs and episodic memory in South Asians from LASI-DAD. Journal of the American Geriatrics Society. 68, S45-S53.
Chintalapati M and Moorjani P+. (2020). Evolution of the mutation rate across primates. Current Opinion in Genetics & Development. 62, 58-64.
2019
Narasimhan VM§, Patterson N§, Moorjani P*, Lazaridis I, Lipson M, Mallick S, Rohland N, Bernardos R, Kim AM, Nakatsuka N, Olalde I, Coppa A, Mallory M, Moiseyev V, Monge J, Olivieri LM, Adamski N, Alex N, Broomandkhoshbacht N, Candilio F, Cheronet O, Culleton BJ, Ferry M, Fernandes D, Gamarra B, Gaudio D, Hajdinjak M, Harney E, Harper TK, Keating D, Lawson A, Michel M, Novak M, Oppenheimer J, Rai R, Sirak K, Slon V, Stewardson K, Zhang Z, Akhatov G, Bagashev A, Baitanayev B, Bonora GL, Chikisheva T, Derevianko A, Dmitry E, Douka K, Dubova N, Epimakhov A, Freilich S, Fuller D, Goryachev A, Gromov A, Hanks B, Judd M, Kazizov E, Khokhlov A, Kitov E, Kupriyanova E, Kuznetsov P, Luiselli D, Maksudov M, Meiklejohn C, Merrett DC, Micheli R, Mochalov O, Muhammed Z, Mustafakulov S, Nayak A, Petrovna RM, Pettner D, Potts R, Razhev D, Sarno S, Sikhymbaevae K, Slepchenko SM, Stepanova N, Svyatko S, Vasilyev S, Vidale M, Voyakin D, Yermolayeva A, Zubova A, Shinde VS, Lalueza-Fox C, Meyer M, Anthony D, Boivin N*, Thangaraj K*, Kennett D*, Frachetti M*, Pinhasi R*, Reich D*. (2019). The formation of human populations in South and Central Asia. Science. 365, eaat7487. Available on bioRxiv. * Co-directed this work.
Featured in: Science News, The Hindu.
Riesenberg S, Chintalapati M, Macak D, Kanis P, Maricic T, Pääbo S. (2019). Simultaneous precise editing of multiple genes in human cells. Nucleic Acids Research. https://doi.org/10.1093/nar/gkz669.
2018
Gao Z, Moorjani P, Amster G, Przeworski M. (2019). Overlooked roles of DNA damage and maternal age in generating human germline mutations. Proceedings of the National Academy of Sciences. 116, 9491-9500. Available on bioRxiv.
2017
, , , , ,, , , , , , , , , , , K. (2017). The promise of discovering population-specific disease-associated genes in South Asia. Nature genetics. 49, 1403. Available on bioRxiv.
Featured in: New York Times, Broad
2016
Moorjani P*,+, Gao Z*,+, and Przeworski M+. (2016). Human germline mutation and the erratic evolutionary clock. PLoS biology. 14, e2000744. Older version on bioRxiv.
Featured in: The Conversation
Moorjani P *,+, Amorim CE *, Arndt P, and Przeworski M+. (2016). Variation in the molecular clock in primates. Proceedings of the National Academy of Sciences. 113, 10607-10612. Older version on bioRxiv.
Featured in: The Guardian
Moorjani P+, Sankararaman S, Fu Q, Przeworski M, Patterson N, Reich D+. (2016). A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years. Proc Natl Acad Sci USA. May 17;113(20):5652-7. doi: 10.1073/pnas.1514696113. Older version on bioRxiv.
Featured in: Popular Archaeology
2014
Fu Q, Li H, Moorjani P, Jay F, Slepchenko SM, Bondarev AA, Johnson PL, Aximu-Petri A, Prüfer K, et al. (2014). Genome sequence of a 45,000-year-old modern human from western Siberia. Nature. 514(7523):445-9. doi: 10.1038/nature13810.
Featured in: The Guardian, Harvard Gazette, Nature News
Yu D, Mathews CA, Scharf JM,Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G,Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH,Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SM, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL,King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, et al. (2014). Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette’s syndrome and OCD. Am J Psychiatry. Jan; 172(1):82-93. doi: 10.1176/appi.ajp.2014.13101306.
Lipson M, Loh PR, Patterson N, Moorjani P, Ko YC, Stoneking M, Berger B, Reich D. (2014). Reconstructing Austronesian population history in Island Southeast Asia. Nature Communications. Aug 19;5:4689. doi: 10.1038/ncomms5689. Older version on bioRxiv.
Prüfer K, Racimo F, Patterson N, Jay F, Sankararaman S, Sawyer S, Heinze A, Renaud G, Sudmant PH, de Filippo C, Li H, Mallick S, Dannemann M, Fu Q, Kircher M, Kuhlwilm M, Lachmann M, Meyer M, Ongyerth M, Siebauer M, Theunert C, Tandon A, Moorjani P, et al. (2014). The complete genome sequence of a Neanderthal from the Altai Mountains. Nature. Jan 2;505(7481):43-9. doi: 10.1038/nature12886.
Featured in: New York Times, National Geographic
2013
Moorjani P*,+, Thangaraj K*, Patterson N, Lipson M, Loh PR, Govindaraj P, Berger B, Reich D, Singh L+. (2013). Genetic evidence for recent population mixture in India. American Journal of Human Genetics. Sep 5;93(3):422-38. doi: 10.1016/j.ajhg.2013.07.006.
Featured in: Science, Boston Globe, Fountain Ink, BBC, INDIA TODAY, The Hindu
Moorjani P. (2013) Genetic study of population mixture and its role in human history Harvard, University.
Moorjani P+, Patterson N, Loh PR, Lipson M, Kisfali P, Melegh BI, Bonin M, Kádaši L, Rieß O, Berger B, Reich D, Melegh B+. (2013). Reconstructing Roma history from genome-wide data. PLoS One. 8(3):e58633. doi: 10.1371/journal.pone.0058633. Older version on arXiv.
Loh P, Lipson M, Patterson P, Moorjani P, Pickrell J, Reich D, Berger B. (2013). Inference of Admixture Parameters in Human Populations Using Weighted Linkage Disequilibrium. Genetics. 193, 1233-1254. Older version on arXiv.
Haber M, Gauguier D, Youhanna S, Patterson N, Moorjani P, Platt D, Wells S, Bertranpetit J, Tyler-Smith C, Comas D, Zalloua P. (2013). Genome-wide diversity in the levant reveals recent structuring by culture. PLoS genetics. 9(2) DOI: 10.1371/journal.pgen.1003316.
2012
Patterson N, Moorjani P, Luo Y, Mallick S, Rohland N, Zhan Y, Genschoreck T, Webster T, and Reich DE. (2012). Ancient Admixture in Human History. Genetics. 2012 Sep; 112.145037.
Scharf J, Yu D, Matthews C, Neale BM, Stewart E, Fagerness J, Evans P, Gamazon E, Edlund C, Service K, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis L, Han B, Crane J, Moorjani P, et al. (2012). Genome-wide association study of Tourette’s syndrome. Molecular Psychiatry. doi: 10.1038/mp.2012.69.
2011
Shah AM*, Tamang R*, Moorjani P*, Rani DS et al. (2011). Indian Siddis: African Descendants with Indian Admixture. American Journal of Human Genetics. 89(1):154-61.
Moorjani P+, Patterson N, Hirschhorn JN, Keinan A, Hao L, Atzmon G, Burns ER, Ostrer H, Price A and Reich DE+. (2011). The History of African Gene Flow into Southern Europeans, Levantines and Jews. PLoS Genetics. 7(4):e1001373.
Featured in: Harvard Gazette, Science Daily
Amstadter AB, Nugent NR, Yang BZ, Miller A, Siburian R, Moorjani P, Heldt E et al. (2011). Corticotrophin-releasing Hormone Type 1 Receptor Gene (CRHR1) Variants Predict Posttraumatic Stress Disorder Onset and Course in Pediatric Injury Patients. Disease Markers. 30(2-3):89-99.
2010
Blaya C, Salum GA, Moorjani P, Seganfredo AC et al. (2010). Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): Association and interaction with childhood trauma and parenting. Neuroscience Letters. 485(1):11-5.
Schuster SC, Miller W, Ratan A, Tomsho LP, Giardine B, Kasson LR, Harris RS, Petersen DC, Zhao F, Qi J, Alkan C, Kidd JM, Sun Y, Drautz DI, Bouffard P, Muzny DM, Reid JG, Nazareth LV, Wang Q, Burhans R, Riemer C, Wittekindt NE, Moorjani P et al. (2010). Complete Khoisan and Bantu genomes from southern Africa. Nature. 463(7283):943-7.
2009
Blaya C, Moorjani P, Salum GA, Gonalves L,Weiss LA, et al. (2009). Preliminary evidence of association between EFHC2, a gene implicated in fear recognition, and harm avoidance. Neuroscience Letters. 452(1):84-86.
2008
Scharf J, Moorjani P, Fagerness JA, Platko J, Illmann C et al. (2008). The Tourette Syndrome Consortium. Lack of Association to SLITRK1 var321 and Tourette Syndrome in a large family based association study. Neurology. 70(16 Pt 2):1495-6.
Perlis RH, Moorjani P, Fagerness JA, Purcell S, Rush AJ et al. (2008). Pharmacogenetic analysis of genes implicated in rodent models of antidepression response: Association of TREK1 and treatment resistance in the STAR*D study. Neuropsychopharmacology. 33(12): 2810-9.
2006
Moorjani P. (2006). Analysis of Genes with KB Sites: Possible Regulation by SpNFkB in the Purple Sea Urchin, Strongylocentrotus Purpuratus. George Washington University.
Terwilliger DP, Buckley KM, Mehta D, Moorjani PG, Smith LC. (2006). Unexpected diversity displayed in cDNAs expressed by the immune cells of the purple sea urchin, Strongylocentrotus purpuratus. Physiol Genomics. 26:134-144.
Moorjani Lab 