Publications

Google Scholar

Group members shown in bold, * equal contribution, + corresponding author.

2023

Moorjani P and Hellenthal G. Methods for Assessing Population Relationships and History from Genomic Data. Annu. Rev. Genomics & Human Genetics, https://doi.org/10.1146/annurev-genom-111422-025117.

Gao Z+, Zhang Y, Cramer N, Przeworski M, Moorjani P+ (2022). Limited role of generation time changes in driving the evolution of the mutation spectrum in humans. eLife 12, e81188. DOI: https://doi.org/10.7554/eLife.81188. Also on bioRxiv.

Zhao W, Smith J, Wang YZ, Chintalapati M, Ammous F, Yu M, Moorjani P, Ganna A, Gross A, Dey S, Benerjee J, Chatterjee P, Dey A, Lee J, Sharon L. R. Kardia. Polygenic risk scores for Alzheimer’s disease and general cognitive function are associated with measures of cognition in older South Asians from LASI-DAD. J Gerontol A Biol Sci Med Sci. 2023 Feb 14;. doi: 10.1093/gerona/glad057.

2022

Tournebize R+, Chu G and Moorjani P+. (2022). Reconstructing the history of founder events using genome-wide patterns of allele sharing across individuals. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1010243. Also on bioRxiv.

              Featured in: Berkeley News, the Daily Californian, Science Daily, and Science et Avenir.

Chintalapati M+, Patterson N+, Moorjani P+. (2022) Reconstructing the spatiotemporal patterns of admixture during the European Holocene using a novel genomic dating method. eLife. DOI: https://doi.org/10.7554/eLife.77625. Also on bioRxiv.

          Featured in: Berkeley News, The Naked Scientists podcast.

2021

Bergeron LBesenbacher S, Turner TN, Versoza CJ, Wang RJ, Price AL, Armstrong E, Riera M, Carlson J, Chen HHahn MHarris K, Kleppe ALópez-Nandam E, Moorjani P, Pfeifer SP, Tiley GP, Yoder AD, Zhang G, Schierup MH. Mutationathon: towards standardization in estimates of pedigree-based germline mutation rates. eLife 2022;11:e73577 DOI: 10.7554/eLife.73577. Also on bioRxiv

Kim Y*, Leiserson M*, Moorjani P*, Sharan R*, Wojtowicz D* and Przytycka TM. Mutational Signatures: From Methods to Mechanisms. Annu. Rev. Biomed. Data Sci. 2021.4:189-206. (*listed alphabetically, as is convention in mathematics & computer science)

2020

Wu FStrand AOber CWall JMoorjani P*Przeworski M*. (2020). A comparison of humans and baboons suggests germline mutation rates do not track cell divisions.  PLoS biology. 18, e3000838. Available on bioRxiv. * Co-directed this work.

Smith J, Zhao W, Yu M, Rumfelt, K, Moorjani P, Ganna A, Dey A, Lee J, Kardia S. (2020). Association between Alzheimer’s Disease risk SNPs and episodic memory in South Asians from LASI-DAD.  Journal of the American Geriatrics Society. 68, S45-S53.

Chintalapati  M and Moorjani P+. (2020). Evolution of the mutation rate across primates.  Current Opinion in Genetics & Development. 62, 58-64.

2019

Narasimhan VM§, Patterson N§, Moorjani P*, Lazaridis I, Lipson M, Mallick S, Rohland N, Bernardos R, Kim AM, Nakatsuka N, Olalde I, Coppa A, Mallory M, Moiseyev V, Monge J, Olivieri LM, Adamski N, Alex N, Broomandkhoshbacht N, Candilio F, Cheronet O, Culleton BJ, Ferry M, Fernandes D, Gamarra B, Gaudio D, Hajdinjak M, Harney E, Harper TK, Keating D, Lawson A, Michel M, Novak M, Oppenheimer J, Rai R, Sirak K, Slon V, Stewardson K, Zhang Z, Akhatov G, Bagashev A, Baitanayev B, Bonora GL, Chikisheva T, Derevianko A, Dmitry E, Douka K, Dubova N, Epimakhov A, Freilich S, Fuller D, Goryachev A, Gromov A, Hanks B, Judd M, Kazizov E, Khokhlov A, Kitov E, Kupriyanova E, Kuznetsov P, Luiselli D, Maksudov M, Meiklejohn C, Merrett DC, Micheli R, Mochalov O, Muhammed Z, Mustafakulov S, Nayak A, Petrovna RM, Pettner D, Potts R, Razhev D, Sarno S, Sikhymbaevae K, Slepchenko SM, Stepanova N, Svyatko S, Vasilyev S, Vidale M, Voyakin D, Yermolayeva A, Zubova A, Shinde VS, Lalueza-Fox C, Meyer M, Anthony D, Boivin N*, Thangaraj K*, Kennett D*, Frachetti M*, Pinhasi R*, Reich D*. (2019). The formation of human populations in South and Central Asia. Science. 365, eaat7487. Available on bioRxiv. * Co-directed this work.

Featured in: Science NewsThe Hindu.

Riesenberg S, Chintalapati M, Macak D, Kanis P, Maricic T, Pääbo S. (2019). Simultaneous precise editing of multiple genes in human cells. Nucleic Acids Research. https://doi.org/10.1093/nar/gkz669.

2018

Gao Z, Moorjani P, Amster G, Przeworski M. (2019). Overlooked roles of DNA damage and maternal age in generating human germline mutations.  Proceedings of the National Academy of Sciences. 116, 9491-9500Available on bioRxiv.

2017

Nakatsuka NJ, Moorjani P, Rai N, Sarkar BArti Tandon, Patterson NBhavani GS, Girisha KM, Mustak MS, Srinivasan S, Kaushik AVahab SA, Jagadeesh SM, Satyamoorthy K, Singh L, Reich D, Thangaraj K. (2017). The promise of discovering population-specific disease-associated genes in South Asia. Nature genetics. 49, 1403. Available on bioRxiv.

Featured in: New York TimesBroad

2016

Moorjani P*,+, Gao Z*,+, and Przeworski M+. (2016). Human germline mutation and the erratic evolutionary clock. PLoS biology. 14, e2000744. Older version on bioRxiv.

Featured in: The Conversation

Moorjani P *,+, Amorim CE *, Arndt P, and Przeworski M+. (2016). Variation in the molecular clock in primates. Proceedings of the National Academy of Sciences. 113, 10607-10612. Older version on bioRxiv.

Featured in: The Guardian

Moorjani P+, Sankararaman S, Fu Q, Przeworski M, Patterson N, Reich D+. (2016). A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years. Proc Natl Acad Sci USA. May 17;113(20):5652-7. doi: 10.1073/pnas.1514696113. Older version on bioRxiv.

Featured in: Popular Archaeology

2014

Fu Q, Li H, Moorjani P, Jay F, Slepchenko SM, Bondarev AA, Johnson PL, Aximu-Petri A, Prüfer K, et al. (2014). Genome sequence of a 45,000-year-old modern human from western Siberia. Nature. 514(7523):445-9. doi: 10.1038/nature13810.

   Featured in:  The GuardianHarvard GazetteNature News

Yu D, Mathews CA, Scharf JM,Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G,Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH,Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SM, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL,King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, et al. (2014). Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette’s syndrome and OCDAm J Psychiatry. Jan; 172(1):82-93. doi: 10.1176/appi.ajp.2014.13101306.

Lipson M, Loh PR, Patterson N, Moorjani P, Ko YC, Stoneking M, Berger B, Reich D. (2014). Reconstructing Austronesian population history in Island Southeast AsiaNature Communications. Aug 19;5:4689. doi: 10.1038/ncomms5689. Older version on bioRxiv.

Prüfer K, Racimo F, Patterson N, Jay F, Sankararaman S, Sawyer S, Heinze A, Renaud G, Sudmant PH, de Filippo C, Li H, Mallick S, Dannemann M, Fu Q, Kircher M, Kuhlwilm M, Lachmann M, Meyer M, Ongyerth M, Siebauer M, Theunert C, Tandon A, Moorjani P, et al. (2014). The complete genome sequence of a Neanderthal from the Altai MountainsNature. Jan 2;505(7481):43-9. doi: 10.1038/nature12886.

Featured in: New York TimesNational Geographic

2013

Moorjani P*,+, Thangaraj K*, Patterson N, Lipson M, Loh PR, Govindaraj P, Berger B, Reich D, Singh L+. (2013). Genetic evidence for recent population mixture in India. American Journal of Human Genetics. Sep 5;93(3):422-38. doi: 10.1016/j.ajhg.2013.07.006.

   Featured in: ScienceBoston GlobeFountain InkBBCINDIA TODAYThe Hindu

Moorjani P. (2013) Genetic study of population mixture and its role in human history Harvard, University.

Moorjani P+, Patterson N, Loh PR, Lipson M, Kisfali P, Melegh BI, Bonin M, Kádaši L, Rieß O, Berger B, Reich D, Melegh B+. (2013). Reconstructing Roma history from genome-wide dataPLoS One. 8(3):e58633. doi: 10.1371/journal.pone.0058633. Older version on arXiv.

Loh P, Lipson M, Patterson P, Moorjani P, Pickrell J, Reich D, Berger B. (2013). Inference of Admixture Parameters in Human Populations Using Weighted Linkage Disequilibrium. Genetics. 193, 1233-1254. Older version on arXiv.

Haber M, Gauguier D, Youhanna S, Patterson N, Moorjani P, Platt D, Wells S, Bertranpetit J, Tyler-Smith C, Comas D, Zalloua P. (2013). Genome-wide diversity in the levant reveals recent structuring by culture. PLoS genetics. 9(2) DOI: 10.1371/journal.pgen.1003316.

2012

Patterson N, Moorjani P, Luo Y, Mallick S, Rohland N, Zhan Y, Genschoreck T, Webster T, and Reich DE. (2012). Ancient Admixture in Human History. Genetics. 2012 Sep; 112.145037.

Scharf J, Yu D, Matthews C, Neale BM, Stewart E, Fagerness J, Evans P, Gamazon E, Edlund C, Service K, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis L, Han B, Crane J, Moorjani P, et al. (2012). Genome-wide association study of Tourette’s syndrome. Molecular Psychiatry. doi: 10.1038/mp.2012.69.

2011

Shah AM*, Tamang R*, Moorjani P*, Rani DS et al. (2011). Indian Siddis: African Descendants with Indian Admixture. American Journal of Human Genetics. 89(1):154-61.

Moorjani P+, Patterson N, Hirschhorn JN, Keinan A, Hao L, Atzmon G, Burns ER, Ostrer H, Price A and Reich DE+. (2011). The History of African Gene Flow into Southern Europeans, Levantines and Jews. PLoS Genetics. 7(4):e1001373.

Featured in: Harvard GazetteScience Daily

Amstadter AB, Nugent NR, Yang BZ, Miller A, Siburian R, Moorjani P, Heldt E et al. (2011). Corticotrophin-releasing Hormone Type 1 Receptor Gene (CRHR1) Variants Predict Posttraumatic Stress Disorder Onset and Course in Pediatric Injury Patients. Disease Markers. 30(2-3):89-99.

2010

Blaya C, Salum GA, Moorjani P, Seganfredo AC et al. (2010). Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): Association and interaction with childhood trauma and parenting. Neuroscience Letters. 485(1):11-5.

Schuster SC, Miller W, Ratan A, Tomsho LP, Giardine B, Kasson LR, Harris RS, Petersen DC, Zhao F, Qi J, Alkan C, Kidd JM, Sun Y, Drautz DI, Bouffard P, Muzny DM, Reid JG, Nazareth LV, Wang Q, Burhans R, Riemer C, Wittekindt NE, Moorjani P et al. (2010). Complete Khoisan and Bantu genomes from southern Africa. Nature. 463(7283):943-7.

2009

Blaya C, Moorjani P, Salum GA, Gonalves L,Weiss LA, et al. (2009). Preliminary evidence of association between EFHC2, a gene implicated in fear recognition, and harm avoidance. Neuroscience Letters. 452(1):84-86.

2008

Scharf J, Moorjani P, Fagerness JA, Platko J, Illmann C et al. (2008). The Tourette Syndrome Consortium. Lack of Association to SLITRK1 var321 and Tourette Syndrome in a large family based association study. Neurology. 70(16 Pt 2):1495-6.

Perlis RH, Moorjani P, Fagerness JA, Purcell S, Rush AJ et al. (2008). Pharmacogenetic analysis of genes implicated in rodent models of antidepression response: Association of TREK1 and treatment resistance in the STAR*D study. Neuropsychopharmacology. 33(12): 2810-9.

2006

Moorjani P. (2006). Analysis of Genes with KB Sites: Possible Regulation by SpNFkB in the Purple Sea Urchin, Strongylocentrotus Purpuratus. George Washington University.

Terwilliger DP, Buckley KM, Mehta D, Moorjani PG, Smith LC. (2006). Unexpected diversity displayed in cDNAs expressed by the immune cells of the purple sea urchin, Strongylocentrotus purpuratus. Physiol Genomics. 26:134-144.